|
KMID : 0359320010410030373
|
|
Korean Journal of Veterinary Research
2001 Volume.41 No. 3 p.373 ~ p.380
|
|
|
Phenotypical changes of lymphocyte subsets in5ltrated in the skin lesions induced experimentally by very virulent strain of Marek`s disease virus in chickens
|
|
조경오/Cho, Kyoung Oh
|
|
|
Abstract
|
|
|
|
Marek´s disease virus (MDV) can cause skin lesions including inflammatory to tumorous. The phenotypical changes of lymphocytes infiltrating in the skin lesions induced by MDV were not clear. Therefore, the skin biopsies taken at weekly intervals for 8 weeks from the same specific-pathorgen free chickens inoculated with Md/5 MDV were examined to analysis the phenotypical changes of lymphocytes. Histologically skin lesions progressed from initial inflammatory to late tumorous. Sequentially CD4+ Tlymphocytes increased gradually in number from initial skin lesions and were majo composition cells in the tumor lesions. Regardless of inlfmmatory or tumor lesions, CD8+ T cells and γδ T cells infiltrated particularly in the dermis and subcutaneous on which MDV was actively replicated in the feather follicle epithelium(FFE). In addition, IgG bearing B lymphocytes in considerable number infiltrated in the dermis and subcutaneous tissues. From these results, the development of MDV-induced skin lesions was inflammatory following tumorous. In addition, each CD8+, γδ and CD4+ T cells and B cell might act to protect MDV replication in the FFE or tumor cells which turned on lytic cycle
|
|
|
KEYWORD
|
|
|
|
|
|
FullTexts / Linksout information
|
|
|
|
|
|
Listed journal information
|
|
|